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Angiotensin II evokes hypotension and renal sympathoinhibition from a highly restricted region in the nucleus tractus solitarii

Tan, Peter S P; Potas, Jason; Killinger, Suzanne; Horiuchi, Jouji; Goodchild, Ann K; Pilowsky, Paul M; Dampney, Roger A L


Microinjections of low doses (in the femtomolar or low picomolar range) of angiotensin II (Ang II) into the nucleus tractus solitarii (NTS) evoke depressor responses. In this study we have mapped in the rat the precise location of the subregion within the NTS at which Ang II evokes significant sympathoinhibitory and depressor responses. Microinjections of 1 pmol of Ang II evoked large decreases (≥20% of baseline) in renal sympathetic nerve activity (RSNA), from a highly restricted region in the...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Brain Research
DOI: 10.1016/j.brainres.2004.12.018


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