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Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase)

Gandhi, Neha S; Freeman, Craig; Mancera, Ricardo L; Parish, Christopher

Description

Mammalian heparanase is an endo-glucuronidase associated with cell invasion in cancer metastasis, angiogenesis and inflammation. Heparanase cleaves heparan sulfate proteoglycans in the extracellular matrix and basement membrane, releasing heparin/heparan

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/39510
Source: Glycobiology
DOI: 10.1093/glycob/cwr095

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