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Terminal Deoxynucleotidyl Transferase Establishes andBroadens Antiviral CD8+ T Cell Immunodominance Hierarchies1

Haeryfar, S M Mansour; Hickman, Heather D.; Irvine, Kari R; Tscharke, David; Bennink, Jack R; Yewdell, Jonathan W


The action of TdT on mouse TCR genes accounts for ∼90% of T cell repertoire diversity. We report that in TdT -/- mice, total T CD8+ responses to influenza and vaccinia viruses are reduced by ∼30% relative to wild-type mice. We find that T CD8+ respons

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Immunology


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