Terminal Deoxynucleotidyl Transferase Establishes andBroadens Antiviral CD8+ T Cell Immunodominance Hierarchies1
The action of TdT on mouse TCR genes accounts for ∼90% of T cell repertoire diversity. We report that in TdT -/- mice, total T CD8+ responses to influenza and vaccinia viruses are reduced by ∼30% relative to wild-type mice. We find that T CD8+ respons
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|Source:||Journal of Immunology|
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