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Regulation of protein translation through mRNAstructure influences MHC class I loading andT cell recognition

Tellam, Judy; Smith, Corey; Rist, Michael; Webb, Natasha; Cooper, Leanne; Vuocolo, Tony; Connolly, Geoff; Tscharke, David; Devoy, Michael; Khanna, Rajiv


Many viruses avoid immune surveillance during latent infection through reduction in the synthesis of virally encoded proteins. Although antigen presentation critically depends on the level of viral protein synthesis, the precise mechanism used to regulate the generation of antigenic peptide precursors remains elusive. Here, we demonstrate that a purine overloaded virally encoded mRNA lacking secondary structure significantly impacts the efficiency of protein translation and prevents endogenous...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0801968105


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