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How T Cells Earn the Follicular Rite of Passage

Garcia De Vinuesa, Maria Carola; Cyster, Jason G

Description

The discovery that Bcl-6 was the transcriptional regulator of follicular helper T (Tfh) cells completed the recognition of this population as an effector subset specialized in the provision of help to B cells. Improved reagents and recent models that allow tracking of Bcl-6-expressing T cells have revealed that the decision to become a Tfh cell occurs soon after T cells are primed by dendritic cells and start dividing, before interaction with B cells. The latter are important for sustaining...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/39401
Source: Immunity
DOI: 10.1016/j.immuni.2011.11.001

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