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Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses

Furuya, Yoichi; Chan, Jennifer; Regner, Matthias; Lobigs, Mario; Koskinen, Aulikki; Kok, Tuckweng; Manavis, Jim; Li, Peng; Mullbacher, Arno; Alsharifi, Mohammed

Description

We previously demonstrated that a single dose of nonadjuvanted intranasal γ-irradiated influenza A virus can provide robust protection in mice against both homologous and heterosubtypic challenges, including challenge with an H5N1 avian virus strain. We

dc.contributor.authorFuruya, Yoichi
dc.contributor.authorChan, Jennifer
dc.contributor.authorRegner, Matthias
dc.contributor.authorLobigs, Mario
dc.contributor.authorKoskinen, Aulikki
dc.contributor.authorKok, Tuckweng
dc.contributor.authorManavis, Jim
dc.contributor.authorLi, Peng
dc.contributor.authorMullbacher, Arno
dc.contributor.authorAlsharifi, Mohammed
dc.date.accessioned2015-12-10T21:56:19Z
dc.identifier.issn0022-538X
dc.identifier.urihttp://hdl.handle.net/1885/39374
dc.description.abstractWe previously demonstrated that a single dose of nonadjuvanted intranasal γ-irradiated influenza A virus can provide robust protection in mice against both homologous and heterosubtypic challenges, including challenge with an H5N1 avian virus strain. We
dc.publisherAmerican Society for Microbiology
dc.sourceJournal of Virology
dc.subjectKeywords: perforin; adaptive immunity; adoptive transfer; animal cell; animal cell culture; animal experiment; article; Bagg albino mouse; CD4+ T lymphocyte; CD8+ T lymphocyte; controlled study; cytotoxic T lymphocyte; gamma irradiation; Influenza virus A; Influenz
dc.titleCytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume84
dc.date.issued2010
local.identifier.absfor110804 - Medical Virology
local.identifier.ariespublicationu4020362xPUB176
local.type.statusPublished Version
local.contributor.affiliationFuruya, Yoichi, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChan, Jennifer, Institute of Medical and Veterinary Science
local.contributor.affiliationRegner, Matthias, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLobigs, Mario, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKoskinen, Aulikki, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKok, Tuckweng, Institute of Medical and Veterinary Science
local.contributor.affiliationManavis, Jim, Institute of Medical and Veterinary Science
local.contributor.affiliationLi, Peng, Institute of Medical and Veterinary Science
local.contributor.affiliationMullbacher, Arno, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationAlsharifi, Mohammed, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage4212
local.bibliographicCitation.lastpage4221
local.identifier.doi10.1128/JVI.02508-09
dc.date.updated2016-02-24T10:27:03Z
local.identifier.scopusID2-s2.0-77950831046
local.identifier.thomsonID000276358000010
CollectionsANU Research Publications

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