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Combining data from 2 nested case-control studies of overlapping cohorts to improve efficiency

Salim, Agus; Hultman, Christina; Sparen, Par; Reilly, Marie


Researchers subject to time and budget constraints may conduct small nested case-control studies with individually matched controls to help optimize statistical power. In this paper, we show how precision can be improved considerably by combining data from a small nested case-control study with data from a larger nested case-control study of a different outcome in the same or overlapping cohort. Our approach is based on the inverse probability weighting concept, in which the log-likelihood...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Biostatistics
DOI: 10.1093/biostatistics/kxn016


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