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Double-Walled Carbon Nanotubes as Nanosyringes

Hilder, Tamsyn; Hill, James M

Description

Functionalized nanoparticles and nanotubes may be able to target specific cells, become ingested and then release their contents in response to a chemical trigger. An alternative delivery mechanism, which may offer advantages in drug delivery is the use of a nanosyringe which pierces the cell membrane and injects molecules such as DNA or anticancer drugs directly into the cell. Here, we propose the use of double-walled carbon nanotubes as nanosyringes. By way of illustration we investigate the...[Show more]

dc.contributor.authorHilder, Tamsyn
dc.contributor.authorHill, James M
dc.date.accessioned2015-12-10T21:56:13Z
dc.date.available2015-12-10T21:56:13Z
dc.identifier.issn1546-1955
dc.identifier.urihttp://hdl.handle.net/1885/39325
dc.description.abstractFunctionalized nanoparticles and nanotubes may be able to target specific cells, become ingested and then release their contents in response to a chemical trigger. An alternative delivery mechanism, which may offer advantages in drug delivery is the use of a nanosyringe which pierces the cell membrane and injects molecules such as DNA or anticancer drugs directly into the cell. Here, we propose the use of double-walled carbon nanotubes as nanosyringes. By way of illustration we investigate the suction and expulsion mechanisms, using elementary mechanics and applied mathematical modeling techniques, for both a C60 fullerene and the anticancer drug cisplatin, but similar calculations can be undertaken for any molecule. Some specific guidelines are formulated to assist medical scientists to facilitate nanosyringe development.
dc.publisherAmerican Scientific Publishers
dc.sourceJournal of Computational and Theoretical Nanoscience
dc.subjectKeywords: Cell membranes; Cytology; Drug delivery; Fullerenes; Mechanics; Multiwalled carbon nanotubes (MWCN); Nanocomposites; Nanotubes; Nucleic acids; Organic acids; Platinum compounds; Anti-cancer drugs; Cisplatin; Delivery mechanisms; Functionalized nanoparticl Cisplatin; Fullerene; Loading/Unloading; Mechanics; Nanosyringe
dc.titleDouble-Walled Carbon Nanotubes as Nanosyringes
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume5
dc.date.issued2008
local.identifier.absfor100703 - Nanobiotechnology
local.identifier.ariespublicationu4133361xPUB175
local.type.statusPublished Version
local.contributor.affiliationHilder, Tamsyn, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHill, James M, University of Wollongong
local.bibliographicCitation.issue11
local.bibliographicCitation.startpage2153
local.bibliographicCitation.lastpage2159
local.identifier.doi10.1166/jctn.2008.1112
dc.date.updated2016-02-24T10:36:39Z
local.identifier.scopusID2-s2.0-57849117165
CollectionsANU Research Publications

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