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A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

Lehane, Adele; Hayward, Rhys; Saliba, Kevin; Kirk, Kiaran


Chloroquine resistance in the malaria parasite Plasmodium falciparum has made malaria increasingly difficult to control. Chloroquine-resistant parasites accumulate less chloroquine than their chloroquine-sensitive counterparts; however, the mechanism underlying this remains unclear. The primary site of accumulation and antimalarial action of chloroquine is the internal acidic digestive vacuole of the parasite, the acidity of which is maintained by inwardly-directed H+ pumps, working against the...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Cell Science
DOI: 10.1242/jcs.016758


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