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Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL

Sontani, Yovina; Chapman, Gavin; Papathanasiou, Panagiotis; Dunwoodie, Sally; Goodnow, Christopher; Hoyne, Gerard


To understand the interactions between Notch1 and Ikaros in the evolution of T cell acute lymphoblastic leukemia (T-ALL), we traced the evolution of T-ALL in mice with an inherited Ikaros mutation, Ikzf1 Plstc which inactivates DNA binding. DNA-binding Ikaros repressed Notch1 response in transfected cell lines and in CD4 +8 + (DP) thymocytes from young pre-leukemic Ikzf1 Plstc heterozygous mice. In DP thymocytes, a 50-1000 fold escalation in mRNA for Notch1 target genes Hes1 and Dtx1 preceded...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Leukemia Research
DOI: 10.1016/j.leukres.2011.07.024


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