Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL
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Sontani, Yovina; Chapman, Gavin; Papathanasiou, Panagiotis; Dunwoodie, Sally; Goodnow, Christopher; Hoyne, Gerard
Description
To understand the interactions between Notch1 and Ikaros in the evolution of T cell acute lymphoblastic leukemia (T-ALL), we traced the evolution of T-ALL in mice with an inherited Ikaros mutation, Ikzf1 Plstc which inactivates DNA binding. DNA-binding Ikaros repressed Notch1 response in transfected cell lines and in CD4 +8 + (DP) thymocytes from young pre-leukemic Ikzf1 Plstc heterozygous mice. In DP thymocytes, a 50-1000 fold escalation in mRNA for Notch1 target genes Hes1 and Dtx1 preceded...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/39229 |
Source: | Leukemia Research |
DOI: | 10.1016/j.leukres.2011.07.024 |
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01_Sontani_Cooperation_between_somatic_2011.pdf | 1.3 MB | Adobe PDF | Request a copy |
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