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Estimates of the effect of natural selection on protein-coding content

Yap, Von Bing; Lindsay, Helen; Easteal, Simon; Huttley, Gavin Austin


Analysis of natural selection is key to understanding many core biological processes, including the emergence of competition, cooperation, and complexity, and has important applications in the targeted development of vaccines. Selection is hard to observe directly but can be inferred from molecular sequence variation. For protein-coding nucleotide sequences, the ratio of nonsynonymous to synonymous substitutions (ω) distinguishes neutrally evolving sequences (ω = 1) from those subjected to...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Molecular Biology and Evolution
DOI: 10.1093/molbev/msp232


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