Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses
Chang, Pheh; Barral, Patricia; Fitch, Jessica; Pratama, Alvin; Ma, Cindy; Kallies, Axel; Hogan, Jennifer; Cerundolo, V; Tangye, Stuart; Bittman, Robert; Nutt, Stephen L; Brink, Robert; Godfrey, Dale I; Batista, Facundo D.; Garcia De Vinuesa, Maria Carola
Lipid antigens trigger help from natural killer T cells (NKT cells) for B cells, and direct conjugation of lipid agonists to antigen profoundly augments antibody responses. Here we show that in vivo, NKT cells engaged in stable and prolonged cognate interactions with B cells and induced the formation of early germinal centers. Mouse and human NKT cells formed CXCR5 + PD -1 hi follicular helper NKT cells (NKT FH cells), and this process required expression of the transcriptional repressor Bcl-6,...[Show more]
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