Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes
Assarsson, Erika; Greenbaum, Jason A.; Sundstrom, Magnus; Schaffer, Lana; Hammond, Jennifer A.; Pasquetto, Valerie; Oseroff, Carla; Hendrickson, R Curtis; Lefkowitz, Elliot J; Tscharke, David; Sidney, John; Grey, Howard; Head, Steven R.; Peters, Bjoern; Sette, Alessandro
Vaccinia virus is the prototypic orthopoxvirus and was the vaccine used to eradicate smallpox, yet the expression profiles of many of its genes remain unknown. Using a genome tiling array approach, we simultaneously measured the expression levels of all 223 annotated vaccinia virus genes during infection and determined their kinetics. For 95% of these genes, significant transcript levels were detected. Most remarkably, classification of the genes by their expression profiles revealed 35 genes...[Show more]
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