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DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

Randall, Katrina; Chan, Stephanie; Ma, Cindy; Fung, Ivan; Mei, Angela (Yan); Yabas, Mehmet; Tan, Andy; Arkwright, Peter D; Al Suwairi, Wafaa; Reyes, Saul Oswaldo Lugo; Yamazaki-Nakashimada, Marco A.; Garcia-Cruz, Maria de la Luz; Smart, Joanne M.; Picard, Capucine; Okada, Satoshi; Jouanguy, Emmanuelle; Casanova, Jean-Laurent; Lambe, Teresa; Cornall, Richard J; Russell, Sarah; Oliaro, Jane; Tangye, Stuart; Bertram, Edward; Goodnow, Christopher

Description

In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both species, and in DOCK8-deficient humans, most CD8 T cells displayed an exhausted...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/39046
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20110345

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