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Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

Alic, Nazif; Andrews, Thomas Daniel; Giannakou, MMaria; Papatheodorou, Irene; Slack, Cathy; Hoddinott, Matthew; Cocheme, Helena; Schuster, Eugene; Thornton, Janet; Partridge, Linda


FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila. dFOXO is directly required for transcription of several IIS components and interacting pathways, such as TOR, in the wild-type fly. The genomic locations occupied by dFOXO in adults are different from those observed in larvae or cultured...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Molecular Systems Biology
DOI: 10.1038/msb.2011.36


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