c-Rel is required for the development of thymic Foxp3 + CD4 regulatory T cells
Isomura, Iwao; Palmer, Stephanie; Grumont, Raelene; Bunting, Karen; Hoyne, Gerard; Wilkinson, Nancy; Banerjee, Ashish; Proietto, Anna; Gugasyan, Raffi; Li, Wu; McNally, Alice; Steptoe, Raymond J; Thomas, Ranjeny; Shannon, M Frances; Gerondakis, Steve
During thymopoiesis, a unique program of gene expression promotes the development of CD4 regulatory T (T reg) cells. Although Foxp3 maintains a pattern of gene expression necessary for T reg cell function, other transcription factors are emerging as important determinants of T reg cell development. We show that the NF-κB transcription factor c-Rel is highly expressed in thymic T reg cells and that in c-rel-/- mice, thymic T reg cell numbers are markedly reduced as a result of a T cell-intrinsic...[Show more]
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|Source:||Journal of Experimental Medicine|
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