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Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells

Wang, Yan; An, Ruihua; Dong, Xuesong; Pan, Shangha; Duan, Guowen (Tony); Sun, Xueying


Objective: Arsenic trioxide (ATO) is a potent antitumor agent used to treat acute promyelocytic leukemia, and recently solid tumors including bladder cancers. However, a mechanism to explain its antitumor activity in bladder cancers is unclear. Here, we investigated the role of protein kinase C (PKC) in ATO-induced apoptosis and inhibition of proliferation in bladder cancer cells. Methods: T24 human bladder carcinoma cells were incubated with different concentrations of ATO in the presence or...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Urologia Internationalis
DOI: 10.1159/000200803


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