Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells
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Wang, Yan; An, Ruihua; Dong, Xuesong; Pan, Shangha; Duan, Guowen (Tony); Sun, Xueying
Description
Objective: Arsenic trioxide (ATO) is a potent antitumor agent used to treat acute promyelocytic leukemia, and recently solid tumors including bladder cancers. However, a mechanism to explain its antitumor activity in bladder cancers is unclear. Here, we investigated the role of protein kinase C (PKC) in ATO-induced apoptosis and inhibition of proliferation in bladder cancer cells. Methods: T24 human bladder carcinoma cells were incubated with different concentrations of ATO in the presence or...[Show more]
Collections | ANU Research Publications |
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Date published: | 2009 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/38918 |
Source: | Urologia Internationalis |
DOI: | 10.1159/000200803 |
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01_Wang_Protein_kinase_C_is_involved_2009.pdf | 44.96 kB | Adobe PDF | Request a copy | |
02_Wang_Protein_kinase_C_is_involved_2009.pdf | 61.39 kB | Adobe PDF | Request a copy |
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