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Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis

Larter, Claire; Yeh, Matthew; Van Rooyen, Derrick; Brooling, John; Ghatora, Kamaljit; Farrell, Geoffrey

Description

Background and Aims: Lipid accumulation precedes hepatocellular injury and liver inflammation in non-alcoholic steatohepatitis (NASH). The peroxisome proliferator-activated receptor (PPAR)α regulates hepatic lipid disposal. We studied whether pharmacolog

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/38913
Source: Journal of Gastroenterology and Hepatology
DOI: 10.1111/j.1440-1746.2011.06939.x

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