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Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic beta-Cell at Submaximal Glucose Concentrations

Lamontagne, Julien; Pepin, Emilie; Peyot, Marie-Line; Joly, Erik; Ruderman, Neil; Poitout, Vincent; Madiraju, Murthy S R; Nolan, Christopher; Prentki, Marc


Thiazolidinediones (TZDs) have beneficial effects on glucose homeostasis via enhancement of insulin sensitivity and preservation of β-cell function. How TZDs preserve β-cells is uncertain, but it might involve direct effects via both peroxisome prolifer

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Endocrinology
DOI: 10.1210/en.2008-1557


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