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Different Preparations of Intravenous Immunoglobulin Vary in Their Efficacy to Neutralize Streptococcal Superantigens: Implications for Treatment of Streptococcal Toxic Shock Syndrome

Schrage, Birgit; Duan, Guowen (Tony); Yang, Lily; Fraser, John D.; Proft, Thomas


Eight different batches of intravenous immunoglobulin from 3 different manufacturers were tested for neutralizing activities against all currently known streptococcal superantigens. Statistically significant variation among different intravenous immunoglobulin preparations (P < .0001) and between individual streptococcal superantigens (P < .0001) was observed. These results might be helpful for optimizing the type and dose of intravenous immunoglobulin used in adjunctive therapy for severe...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Clinical Infectious Diseases
DOI: 10.1086/507037


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