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Lifecourse influences on health among British adults: Effects of region of residence in childhood and adulthood.

Strachan, David. P; Rudnicka, Alicja. R; Power, Chris; Shepherd, Peter; Fuller, Elizabeth; Davis, Adrian; Gibb, Ian; Kumari, Meena; Rumley, Anne; Macfarlane, Gary. J; Rahi, Jugnoo; Stansfeld, Stephen; Rodgers, Bryan

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Background: It has been suggested that early life exposures are important determinants of geographical variations in adult diseases. We examined inter-regional migrants in Britain to evaluate the relative importance of early and recent exposures for adult cardiorespiratory risk factors, mental ill-health and sensory function. Methods: A total of 9023 persons born throughout England, Scotland and Wales during 1 week in 1958 were followed periodically through childhood into adulthood. At 44-45...[Show more]

dc.contributor.authorStrachan, David. P
dc.contributor.authorRudnicka, Alicja. R
dc.contributor.authorPower, Chris
dc.contributor.authorShepherd, Peter
dc.contributor.authorFuller, Elizabeth
dc.contributor.authorDavis, Adrian
dc.contributor.authorGibb, Ian
dc.contributor.authorKumari, Meena
dc.contributor.authorRumley, Anne
dc.contributor.authorMacfarlane, Gary. J
dc.contributor.authorRahi, Jugnoo
dc.contributor.authorStansfeld, Stephen
dc.contributor.authorRodgers, Bryan
dc.date.accessioned2015-12-10T21:54:01Z
dc.identifier.issn0300-5771
dc.identifier.urihttp://hdl.handle.net/1885/38753
dc.description.abstractBackground: It has been suggested that early life exposures are important determinants of geographical variations in adult diseases. We examined inter-regional migrants in Britain to evaluate the relative importance of early and recent exposures for adult cardiorespiratory risk factors, mental ill-health and sensory function. Methods: A total of 9023 persons born throughout England, Scotland and Wales during 1 week in 1958 were followed periodically through childhood into adulthood. At 44-45 years, height, body mass index (BMI), blood pressure (BP), glycosylated haemoglobin, total and high-density lipoprotein (HDL) cholesterol, triglycerides, fibrinogen, total immunoglobulin E (IgE), one-second forced expiratory volume (FEV1), hearing threshold at 4kHz, visual impairment, symptoms of depression and anxiety, and chronic widespread pain were measured. Analysis of migration between 12 regions included 3125 cohort members who were examined in a region different to their birthplace. Results: Height, BMI, diastolic BP (DBP), FEV1, log-transformed IgE and hearing threshold varied by region among non-migrants (each P < 0.05). Among inter-regional migrants, the spatial associations with current region, independent of birthplace, followed closely the geographical pattern shown among non-migrants for BMI, DBP and FEV1 (each P < 0.001). In contrast, of the 15 outcomes, only adult height was related to region of birth, after adjustment for region of examination (P = 0.002) Conclusions: Although individual disease risk is predicted by early life factors, early exposures do not explain regional variations in cardiovascular and respiratory risk factors among middle-aged adults in Britain. Geographical inequalities in cardiorespiratory health are more strongly related to factors associated with region of examination that influence obesity, BP and ventilatory function.
dc.publisherOxford University Press
dc.sourceInternational Journal of Epidemiology
dc.subjectKeywords: fibrinogen; glycosylated hemoglobin; high density lipoprotein cholesterol; immunoglobulin E; triacylglycerol; adult; disease; geographical variation; health care; health risk; risk factor; adult; anxiety; article; auditory threshold; birthplace; blood pre
dc.titleLifecourse influences on health among British adults: Effects of region of residence in childhood and adulthood.
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume36
dc.date.issued2007
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationu3962038xPUB166
local.type.statusPublished Version
local.contributor.affiliationStrachan, David. P, University of London
local.contributor.affiliationRudnicka, Alicja. R, St George's University of London
local.contributor.affiliationPower, Chris, University College London (Inst of Child Health)
local.contributor.affiliationShepherd, Peter, Institute of Education (Bedford Group)
local.contributor.affiliationFuller, Elizabeth, National Centre for Social Research
local.contributor.affiliationDavis, Adrian, University of Manchester
local.contributor.affiliationGibb, Ian, Royal Victoria Infirmary
local.contributor.affiliationKumari, Meena, University College London
local.contributor.affiliationRumley, Anne, University of Glasgow
local.contributor.affiliationMacfarlane, Gary. J, University of Aberdeen
local.contributor.affiliationRahi, Jugnoo, Institute of Child Health
local.contributor.affiliationRodgers, Bryan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationStansfeld, Stephen, Queen Mary University of London
local.description.embargo2037-12-31
local.bibliographicCitation.issue3
local.bibliographicCitation.startpage522
local.bibliographicCitation.lastpage531
local.identifier.doi10.1093/ije/dyl309
dc.date.updated2015-12-09T07:22:56Z
local.identifier.scopusID2-s2.0-34249991592
CollectionsANU Research Publications

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