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Prospects for fertility control in the European rabbit(Oryctolagus cuniculus) using myxoma virus-vectored immunocontraception

van Leeuwen, Barbara; Kerr, Peter

Description

Research over the last 15 years has examined whether fertility control can reduce overabundant rabbit populations and whether an effective immunocontraceptive agent can be developed and delivered. The results of this research indicate that for fertility control to have an environmental impact at least 80% of females will need to be infertile and that this infertility will need to be permanent. Epidemiological studies suggest that this level of infertility may be very difficult to obtain with a...[Show more]

dc.contributor.authorvan Leeuwen, Barbara
dc.contributor.authorKerr, Peter
dc.date.accessioned2015-12-10T21:53:35Z
dc.identifier.issn1035-3712
dc.identifier.urihttp://hdl.handle.net/1885/38568
dc.description.abstractResearch over the last 15 years has examined whether fertility control can reduce overabundant rabbit populations and whether an effective immunocontraceptive agent can be developed and delivered. The results of this research indicate that for fertility control to have an environmental impact at least 80% of females will need to be infertile and that this infertility will need to be permanent. Epidemiological studies suggest that this level of infertility may be very difficult to obtain with a recombinant myxoma virus because of competition with field strains of virus. Research with laboratory rabbits using recombinant myxoma virus to deliver an immunocontraceptive antigen demonstrated that it was possible to obtain the required level of infertility using rabbit zona pellucida C as an antigen. However, only ∼50% of animals remained infertile in the medium term. Further research on delivery vector and antigen selection would be needed to produce a practical immunocontraceptive virus for laboratory testing. Such a virus would then need to be optimised for transmissibility before it would be suitable for field testing.
dc.publisherCSIRO Publishing
dc.sourceWildlife Research
dc.subjectKeywords: antigen; disease vector; epidemiology; infertility; laboratory method; lagomorph; viral disease; Animalia; Myxoma virus; Oryctolagus cuniculus
dc.titleProspects for fertility control in the European rabbit(Oryctolagus cuniculus) using myxoma virus-vectored immunocontraception
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume34
dc.date.issued2007
local.identifier.absfor060506 - Virology
local.identifier.absfor100299 - Environmental Biotechnology not elsewhere classified
local.identifier.absfor050202 - Conservation and Biodiversity
local.identifier.ariespublicationu4325460xPUB163
local.type.statusPublished Version
local.contributor.affiliationvan Leeuwen, Barbara, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKerr, Peter, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage511
local.bibliographicCitation.lastpage522
local.identifier.doi10.1071/WR06167
dc.date.updated2015-12-09T07:19:00Z
local.identifier.scopusID2-s2.0-37149033082
CollectionsANU Research Publications

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