Skip navigation
Skip navigation

An epidemiological investigation into an outbreak of rash illness among methadone maintenance clients in Australia

McAnulty, Jeremy M.; Jauncey, Marianne E.; Monger, Claire K.; Hailstone, Susan T.; Alam, Noore; Mannes, Trish F.; Capon, Adam G.; Irvine, Katie; Armstrong, Paul K.; Kaldor, John M.

Description

In late 2004, NSW Health received several reports of a serious desquamating rash among clients of the methadone program. We sought to identify the extent and likely cause of this outbreak. We initiated active surveillance for cases throughout Australia, a survey of dosing points in NSW, and a case control study of clients receiving methadone syrup (MS) at two clinics. Between October 2004 and March 2005, 388 cases were identified, largely in NSW. The dosing point survey found almost all cases...[Show more]

dc.contributor.authorMcAnulty, Jeremy M.
dc.contributor.authorJauncey, Marianne E.
dc.contributor.authorMonger, Claire K.
dc.contributor.authorHailstone, Susan T.
dc.contributor.authorAlam, Noore
dc.contributor.authorMannes, Trish F.
dc.contributor.authorCapon, Adam G.
dc.contributor.authorIrvine, Katie
dc.contributor.authorArmstrong, Paul K.
dc.contributor.authorKaldor, John M.
dc.date.accessioned2015-12-10T21:53:19Z
dc.identifier.issn0959-5236
dc.identifier.urihttp://hdl.handle.net/1885/38483
dc.description.abstractIn late 2004, NSW Health received several reports of a serious desquamating rash among clients of the methadone program. We sought to identify the extent and likely cause of this outbreak. We initiated active surveillance for cases throughout Australia, a survey of dosing points in NSW, and a case control study of clients receiving methadone syrup (MS) at two clinics. Between October 2004 and March 2005, 388 cases were identified, largely in NSW. The dosing point survey found almost all cases were clients prescribed MS (attack rate 4.5%). In multivariate analysis of data from dosing points that dispensed MS, use of take away doses or location of the dosing point in greater western Sydney were associated with illness. In the case control study, MS injection, use of street MS, high doses of MS, frequent takeaway doses, or use of benzodiazepines were associated with illness. Testing found no abnormality in associated batches of MS. Batches of MS temporally associated with the outbreak were quarantined from use and the outbreak subsided. While a direct causal link could not be established, available evidence suggests that a contaminant may have caused the outbreak. Epidemiological analyses are important for assessing concerns about product safety following marketing approval.
dc.publisherCarfax Publishing, Taylor & Francis Group
dc.sourceDrug and Alcohol Review
dc.subjectKeywords: methadone; narcotic agent; acute disease; adult; article; Australia; case control study; cross-sectional study; dose response; drug control; drug dependence treatment; drug eruption; epidemic; epidemiology; female; health survey; human; male; middle aged; Adverse event; Desquamation; Methadone; Opioid pharmacotherapy; Outbreak; Rash
dc.titleAn epidemiological investigation into an outbreak of rash illness among methadone maintenance clients in Australia
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume26
dc.date.issued2007
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationu3962038xPUB162
local.type.statusPublished Version
local.contributor.affiliationMcAnulty , Jeremy.M, New South Wales Health Department
local.contributor.affiliationJauncey, Marianne. E, NSW Health
local.contributor.affiliationMonger, Claire. K. , NSW Health
local.contributor.affiliationHailstone, Susan. T. , NSW Health
local.contributor.affiliationAlam, Noore, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMannes, Trish F. , NSW Health
local.contributor.affiliationCapon, Adam. G, NSW Health
local.contributor.affiliationIrvine, Katie, NSW Health
local.contributor.affiliationArmstrong, Paul K, NSW Health
local.contributor.affiliationKaldor, John M, University of New South Wales
local.description.embargo2037-12-31
local.bibliographicCitation.issue3
local.bibliographicCitation.startpage321
local.bibliographicCitation.lastpage331
local.identifier.doi10.1080/09595230701247798
dc.date.updated2015-12-09T07:17:19Z
local.identifier.scopusID2-s2.0-34147109420
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_McAnulty _An_epidemiological_2007.pdf251.57 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator