Walweel, K; Li, Jioa; Molenaar, Peter; Imtiaz, Mohammad S; Quail, Anthony; dos Remedios, Cristobal; Beard, Nicole; Dulhunty, Angela; vanHelden, Dirk F; Laver, Derek R
Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca2+ and Mg2+ plays a key role in determining cardiac contraction and rhythmicity, but their role in regulating the human RyR2 remains poorly defined. The Ca2+-and Mg2+-dependent regulation of human RyR2 was recorded in artificial lipid bilayers in the presence of 2 mM ATP and compared with that in two commonly used animal models for RyR2 function (rat and sheep). Human RyR2 displayed cytoplasmic Ca2+ activation (Ka = 4 μM)...[Show more]
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