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Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum

Walweel, K; Li, Jioa; Molenaar, Peter; Imtiaz, Mohammad S; Quail, Anthony; dos Remedios, Cristobal; Beard, Nicole; Dulhunty, Angela; vanHelden, Dirk F; Laver, Derek R

Description

Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca2+ and Mg2+ plays a key role in determining cardiac contraction and rhythmicity, but their role in regulating the human RyR2 remains poorly defined. The Ca2+-and Mg2+-dependent regulation of human RyR2 was recorded in artificial lipid bilayers in the presence of 2 mM ATP and compared with that in two commonly used animal models for RyR2 function (rat and sheep). Human RyR2 displayed cytoplasmic Ca2+ activation (Ka = 4 μM)...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/38169
Source: Journal of General Physiology
DOI: 10.1085/jgp.201311157

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