Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum
Walweel, K; Li, Jioa; Molenaar, Peter; Imtiaz, Mohammad S; Quail, Anthony; dos Remedios, Cristobal; Beard, Nicole; Dulhunty, Angela; vanHelden, Dirk F; Laver, Derek R
Description
Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca2+ and Mg2+ plays a key role in determining cardiac contraction and rhythmicity, but their role in regulating the human RyR2 remains poorly defined. The Ca2+-and Mg2+-dependent regulation of human RyR2 was recorded in artificial lipid bilayers in the presence of 2 mM ATP and compared with that in two commonly used animal models for RyR2 function (rat and sheep). Human RyR2 displayed cytoplasmic Ca2+ activation (Ka = 4 μM)...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2014 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/38169 |
Source: | Journal of General Physiology |
DOI: | 10.1085/jgp.201311157 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Walweel_Differences_in_the_regulation_2014.pdf | 1.2 MB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 20 July 2017/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator