Reuter, Fabian; Bade, Steffen; Hirst, Timothy; Frey, Andreas
Endowing mucosal vaccines with ligands that target antigen to mucosal lymphoid tissues may improve immunization efficacy provided that the ligands withstand the proteolytic environment of the gastro-intestinal tract until they reach their destination. Our aim was to investigate whether and how three renowned ligands - Ulex europaeus agglutinin I and the B subunits of cholera toxin and E. coli heat-labile enterotoxin - master this challenge. We assessed the digestive power of natural murine...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.