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Bystander protein protects potential vaccine-targeting ligands against intestinal proteolysis

Reuter, Fabian; Bade, Steffen; Hirst, Timothy; Frey, Andreas

Description

Endowing mucosal vaccines with ligands that target antigen to mucosal lymphoid tissues may improve immunization efficacy provided that the ligands withstand the proteolytic environment of the gastro-intestinal tract until they reach their destination. Our aim was to investigate whether and how three renowned ligands - Ulex europaeus agglutinin I and the B subunits of cholera toxin and E. coli heat-labile enterotoxin - master this challenge. We assessed the digestive power of natural murine...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/38136
Source: Journal of Controlled Release
DOI: 10.1016/j.jconrel.2009.03.015

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