Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms
Mino, Takashi; Murakawa, Kasuhiro; Fukao, Akira; Vandenbon, Alexis; Wessels, Hans-Hermann; Ori, Daisuke; Uehata, Takuya; Tartey, Sarang; Akira, Shizuo; Suzuki, Yutaka; Garcia De Vinuesa, Maria Carola; Ohler, Uwe; Standley, Daron M.; Landthaler, Markus; Fujiwara, Toshinobu; Takeuchi, Osamu
Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-related mRNAs and maintenance of immune homeostasis. However, their mechanistic relationship has yet to be clarified. Here, we show that, although Regnase-1 and Roquin regulate an overlapping set of mRNAs via a common stem-loop structure, they function in distinct subcellular locations: ribosome/endoplasmic reticulum and processing-body/stress granules, respectively. Moreover, Regnase-1 specifically cleaves...[Show more]
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