Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms
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Mino, Takashi; Murakawa, Kasuhiro; Fukao, Akira; Vandenbon, Alexis; Wessels, Hans-Hermann; Ori, Daisuke; Uehata, Takuya; Tartey, Sarang; Akira, Shizuo; Suzuki, Yutaka; Garcia De Vinuesa, Maria Carola; Ohler, Uwe; Standley, Daron M.; Landthaler, Markus; Fujiwara, Toshinobu; Takeuchi, Osamu
Description
Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-related mRNAs and maintenance of immune homeostasis. However, their mechanistic relationship has yet to be clarified. Here, we show that, although Regnase-1 and Roquin regulate an overlapping set of mRNAs via a common stem-loop structure, they function in distinct subcellular locations: ribosome/endoplasmic reticulum and processing-body/stress granules, respectively. Moreover, Regnase-1 specifically cleaves...[Show more]
Collections | ANU Research Publications |
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Date published: | 2015 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/38041 |
Source: | Cell |
DOI: | 10.1016/j.cell.2015.04.029 |
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01_Mino_Regnase-1_and_Roquin_Regulate_2015.pdf | 4.93 MB | Adobe PDF | Request a copy |
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