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Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity

Ramshaw, Ian; Ranasinghe, Charani


In this article, we discuss the advantages and progress made with heterologous prime-boost vaccination strategies. Although the consecutive use of DNA and recombinant viral vectors induce greatly enhanced and sustained levels of both cell-mediated and humoral immunity in preclinical models, the results have not yet been translated to clinical use. Despite this, there is still a high level of optimism that these strategies offer the best hope for the development of vaccines against diseases for...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Expert Review of Vaccines
DOI: 10.1586/erv.09.86


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