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IL-10 + CTLA-4 + Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation

Altin, John; Goodnow, Christopher; Cook, Matthew


Activated Th cells influence other T cells via positive feedback circuits that expand and polarize particular types of response, but little is known about how they may also initiate negative feedback against immunopathological reactions. In this study, we demonstrate the emergence, during chronic inflammation, of GATA-3+ Th2 inhibitory (Th2i) cells that express high levels of inhibitory proteins including IL-10, CTLA-4, and granzyme B, but do so independently of Foxp3. Whereas other Th2...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1102994


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