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Gene signature of Stromal Cells which support Dendritic Cell Development

Despars, Genevieve; Periasamy, Pravin; Tan, Jonathan; Abbey, Janice; O'Neill, Terence; O'Neill, Helen

Description

Spleen stromal cells are critical determinants of dendritic cell (DC) development in spleen. The spleen stromal line, namely STX3, supports DC differentiation in vitro from overlaid bone marrow cells while the lymph node stromal line, namely 2RL22, does not. Here we have characterised the hematopoietic support capacity of each stroma, and analysed lineage origin of the stromal cell lines by gene profiling using microarrays. Stromal co-culture experiments were performed using bone marrow cells...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/37932
Source: Stem Cells and Development
DOI: 10.1089/scd.2007.0170

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