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Purine nucleobase transport in the intraerythrocytic malaria parasite

Downie, Megan; Saliba, Kevin; Broer, Stefan; Howitt, Susan; Kirk, Kiaran


Hypoxanthine, a nucleobase, serves as the major source of the essential purine group for the intraerythrocytic malaria parasite. In this study we have measured the uptake of hypoxanthine, and that of the related purine nucleobase adenine, by mature blood-stage Plasmodium falciparum parasites isolated from their host cells by saponin-permeabilisation of the erythrocyte and parasitophorous vacuole membranes. The uptake of both [3H]hypoxanthine and [3H]adenine was comprised of at least two...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: International Journal for Parasitology
DOI: 10.1016/j.ijpara.2007.07.005


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