Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children
Craig, Jonathan; Simpson, Judy M; Williams, Gabrielle; Lowe, Alison; Reynolds, Graham; McTaggart, Steven; Hodson, Elisabeth; Carapetis, Jonathan; Cranswick, Noel; Smith, Grahame; Irwig, Les; Caldwell, Patrina; Hamilton, Sana; Roy, Leslie
BACKGROUND: Antibiotics are widely administered to children with the intention of preventing urinary tract infection, but adequately powered, placebo-controlled trials regarding efficacy are lacking. This study from four Australian centers examined whether low-dose, continuous oral antibiotic therapy prevents urinary tract infection in predisposed children. METHODS: We randomly assigned children under the age of 18 years who had had one or more microbiologically proven urinary tract infections...[Show more]
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|Source:||New England Journal of Medicine|
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