Are Current or Future Mesothelioma Epidemics in Hong Kong the Tragic Legacy of Uncontrolled Use of Asbestos in the Past?
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Tse, Lap Ah; Yu, Ignatius T S; Goggins, William; Clements, Mark; Wang, Xiao Rong; Au, Joseph Siu-kie; Yu, Kai Shing
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BACKGROUND: Because of the long latent period of asbestos-related mesothelioma, investigators suggest that the high incidence of this disease will continue in the coming decades. OBJECTIVES: We describe the time trends of mesothelioma incidence and its relationship to historical consumption of asbestos in Hong Kong and project future trends of mesothelioma incidence. METHODS: We obtained local annual consumption of total asbestos for 1960-2006 (converted to kilograms per person per year)....[Show more]
dc.contributor.author | Tse, Lap Ah | |
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dc.contributor.author | Yu, Ignatius T S | |
dc.contributor.author | Goggins, William | |
dc.contributor.author | Clements, Mark | |
dc.contributor.author | Wang, Xiao Rong | |
dc.contributor.author | Au, Joseph Siu-kie | |
dc.contributor.author | Yu, Kai Shing | |
dc.date.accessioned | 2015-12-08T22:45:10Z | |
dc.identifier.issn | 0091-6765 | |
dc.identifier.uri | http://hdl.handle.net/1885/37710 | |
dc.description.abstract | BACKGROUND: Because of the long latent period of asbestos-related mesothelioma, investigators suggest that the high incidence of this disease will continue in the coming decades. OBJECTIVES: We describe the time trends of mesothelioma incidence and its relationship to historical consumption of asbestos in Hong Kong and project future trends of mesothelioma incidence. METHODS: We obtained local annual consumption of total asbestos for 1960-2006 (converted to kilograms per person per year). Age-standardized incidence rates (ASIRs) of mesothelioma were computed and depicted on graphs using the centered moving average method. Indirectly standardized rates were regressed on a transformation of consumption data that assumed that the latency between asbestos exposure and mesothelioma diagnosis followed a normal distribution with a mean ± SD of 42 ± 10.5 years. RESULTS: ASIRs for males started to increase substantially in 1994 and were highest in 2004; for females, ASIRs climbed in the 1980s and in the early 1990s but have fluctuated without obvious trends in recent years. The highest asbestos consumption level in Hong Kong was in 1960-1963 and then decreased sharply afterward. Using past asbestos consumption patterns, we predict that the mesothelioma incidence rate for males will peak in 2009, with the number of cases peaking in 2014, and then slowly decline in the coming decades. CONCLUSIONS: Hong Kong experienced an epidemic of mesothelioma from 2000 to 2006 that corresponded with the peak of local asbestos consumption in the early 1960s assuming an average latent period of 42 years. The incidence is anticipated to decline in the coming decades but may not decrease back to the background risk level (the risk unrelated to asbestos exposure). | |
dc.publisher | National Institute of Environmental Sciences | |
dc.source | Environmental Health Perspectives | |
dc.subject | Keywords: asbestos; adult; aged; article; cancer diagnosis; cancer epidemiology; cancer incidence; dose time effect relation; environmental exposure; female; groups by age; Hong Kong; human; major clinical study; male; mesothelioma; priority journal; sex difference Asbestos; Epidemic; Incidence; Mesothelioma; Time trends | |
dc.title | Are Current or Future Mesothelioma Epidemics in Hong Kong the Tragic Legacy of Uncontrolled Use of Asbestos in the Past? | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 118 | |
dc.date.issued | 2010 | |
local.identifier.absfor | 111706 - Epidemiology | |
local.identifier.ariespublication | u4637548xPUB152 | |
local.type.status | Published Version | |
local.contributor.affiliation | Tse, Lap Ah, Chinese University of Hong Kong | |
local.contributor.affiliation | Yu, Ignatius T S, Chinese University of Hong Kong | |
local.contributor.affiliation | Goggins, William, Chinese University of Hong Kong | |
local.contributor.affiliation | Clements, Mark, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Wang, Xiao Rong, Chinese University of Hong Kong | |
local.contributor.affiliation | Au, Joseph Siu-kie, Queen Elizabeth Hospital - Hong Kong | |
local.contributor.affiliation | Yu, Kai Shing, Chinese University of Hong Kong | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 3 | |
local.bibliographicCitation.startpage | 382 | |
local.bibliographicCitation.lastpage | 386 | |
local.identifier.doi | 10.1289/ehp.0900868 | |
dc.date.updated | 2016-02-24T11:16:23Z | |
local.identifier.scopusID | 2-s2.0-77649206797 | |
Collections | ANU Research Publications |
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