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Immunocontraceptive effects on female rabbits infected with recombinant myxoma virus expressing rabbit ZP2 or ZP3

Mackenzie, S.M.; McLaughlin, E A; Perkins, Harvey; French, N.; Sutherland, Tara D; Jackson, R.J.; Inglis, Barbara; Muller, W J; van Leeuwen, Barbara; Robinson, A.J.; Kerr, Peter


Recombinant myxoma viruses expressing rabbit zona pellucida 2 (rZP2) or rabbit zona pellucida 3 (rZP3) glycoproteins were constructed and tested in domestic rabbits to assess their potential to induce autoimmune infertility. The recombinant virus expressing rZP2 had no effect on fertility or ovarian histology, despite all animals developing antibodies against the rZP2 antigen. However, recombinant viruses expressing rZP3 induced infertility in 70% of animals at the first breeding. Serum...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Biology of Reproduction
DOI: 10.1095/biolreprod.105.046268


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