Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study
Travis, Ruth; Reeves, Gillian K; Green, Jane; Bull, Diana; Tipper, Sarah J; Baker, Krys; Beral, Valerie; Peto, Richard; Bell, John I; Zelenkia, Diana; Lathrop, Mark; Banks, Emily; Million Women Study, Collaborators
Background: Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for evidence of gene-environment interactions, we compared genotypic relative risks for breast cancer across the other risk factors in a large UK prospective study. Methods: We tested gene-environment interactions in 7610 women who developed...[Show more]
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