Regner, Matthias; Pavlinovic, Lisa; Koskinen, Aulikki; Young, Nicolie; Trapani, Joseph A; Mullbacher, Arno
Cytotoxic T (Tc) cells lyse target cells via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell cytosol results in apoptosis, and in the absence of gzm A and B the induction of apoptosis is severely impaired. However, using in vivo Tc cell killing assays, we find that virus-immune, gzm A x B-deficient (gzmAxB -/-) mice are competent to eliminate adoptively transferred target cells pulsed with an immunodominant Tc cell determinant...[Show more]
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