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Cutting edge: Rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B

Regner, Matthias; Pavlinovic, Lisa; Koskinen, Aulikki; Young, Nicolie; Trapani, Joseph A; Mullbacher, Arno

Description

Cytotoxic T (Tc) cells lyse target cells via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell cytosol results in apoptosis, and in the absence of gzm A and B the induction of apoptosis is severely impaired. However, using in vivo Tc cell killing assays, we find that virus-immune, gzm A x B-deficient (gzmAxB -/-) mice are competent to eliminate adoptively transferred target cells pulsed with an immunodominant Tc cell determinant...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/37599
Source: Journal of Immunology
DOI: 10.4049/jimmunol.0900466

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