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The role of interchain heterodisulfide formation in activation of the human common β and mouse β IL-3 receptors

Mirza, Shamaruh; Chen, Jinglong; Murphy, James M; Young, Ian

Description

The cytokines, interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte-macrophage colony-stimulating factor (GM-CSF), exhibit overlapping activities in the regulation of hematopoietic cells. In humans, the common β (βc) receptor is shared by the thr

dc.contributor.authorMirza, Shamaruh
dc.contributor.authorChen, Jinglong
dc.contributor.authorMurphy, James M
dc.contributor.authorYoung, Ian
dc.date.accessioned2015-12-08T22:44:51Z
dc.identifier.issn0021-9258
dc.identifier.urihttp://hdl.handle.net/1885/37582
dc.description.abstractThe cytokines, interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte-macrophage colony-stimulating factor (GM-CSF), exhibit overlapping activities in the regulation of hematopoietic cells. In humans, the common β (βc) receptor is shared by the thr
dc.publisherAmerican Society for Biochemistry and Molecular Biology Inc
dc.sourceJournal of Biological Chemistry
dc.subjectKeywords: Binding epitopes; Cysteine residues; Cytokines; Granulocyte-macrophage colony-stimulating factors; Hematopoietic cell; High affinity binding; Interleukin-3; Interleukin-5; Isoforms; Ligand binding; Ligand-binding residues; N-terminal domains; N-terminals;
dc.titleThe role of interchain heterodisulfide formation in activation of the human common β and mouse β IL-3 receptors
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume285
dc.date.issued2010
local.identifier.absfor060112 - Structural Biology (incl. Macromolecular Modelling)
local.identifier.ariespublicationf2965xPUB151
local.type.statusPublished Version
local.contributor.affiliationMirza, Shamaruh, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChen, Jinglong, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMurphy, James M, The Walter and Eliza Hall Institute of Medical Research
local.contributor.affiliationYoung, Ian, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue32
local.bibliographicCitation.startpage24759
local.bibliographicCitation.lastpage24768
local.identifier.doi10.1074/jbc.M109.097881
dc.date.updated2016-02-24T08:14:41Z
local.identifier.scopusID2-s2.0-77955282871
local.identifier.thomsonID000280542100048
CollectionsANU Research Publications

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