Latitudinal variation in incidence and type of first central nervous system demyelinating events
Taylor, Bruce; Dear, Keith; Kilpatrick, Trevor J; Pender, M P; Van Der Mei, Ingrid; Chapman, Caron; Coulthard, Alan; Dwyer, Terry; McMichael, Anthony; Valery, Patricia C; Williams, David; Ponsonby, Anne-Louise; Lucas, Robyn
Increasing prevalence and variable geographic patterns of occurrence of multiple sclerosis suggest an environmental role in causation. There are few descriptive, population-level, data on whether such variability applies to first demyelinating events (FDEs). We recruited 216 adults (18-59 years), with a FDE between 1 November 2003 and 31 December 2006 in a multi-center incident case-control study in four locations on the south-eastern and eastern seaboard of Australia, spanning latitudes 27°...[Show more]
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