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Transcriptional Repressor Blimp-1 Promotes CD8 + T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

Rutishauser, Rachel; Martins, Gislaine; Kalachikov, Sergey; Chandele, Anmol; Parish, Ian; Meffre, Eric; Jacob, Joshy; Calame, Kathryn; Kaech, Susan

Description

During acute infections, a small population of effector CD8+ T cells evades terminal differentiation and survives as long-lived memory T cells. We demonstrate that the transcriptional repressor Blimp-1 enhanced the formation of terminally differentiated

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/37486
Source: Immunity
DOI: 10.1016/j.immuni.2009.05.014

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