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5-HT obesity medication efficacy via POMC activation is maintained during aging

Burke, Luke K; Doslikova, Barbora; D’Agostino, Giusepp; Garfield, Alastair S; Farooq, Gala; Burdako, Denis; Low, Malcom J; Rubenstein, Marcelo; Evans, Mark; Billups, Brian; Heisler, Lora

Description

The phenomenon commonly described as the middle-age spread is the result of elevated adiposity accumulation throughout adulthood until late middle-age. It is a clinical imperative to gain a greater understanding of the underpinnings of age-dependent obesity and, in turn, how these mechanisms may impact the efficacy of obesity treatments. In particular, both obesity and aging are associated with rewiring of a principal brain pathway modulating energy homeostasis, promoting reduced activity of...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/37480
Source: Endocrinology
DOI: 10.1210/en.2014-1223

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