Sun exposure and vitamin D are independent risk factors for CNS demyelination
Ponsonby, Anne-Louise; Dear, Keith; Valery, Patricia C; Pender, Michael; Taylor, B V; Kilpatrick, Trevor J; Dwyer, Terry; Coulthard, Alan; Chapman, Caron; Van Der Mei, Ingrid; Williams, David; McMichael, Anthony; Lucas, Robyn
Objectives: To examine whether past and recent sun exposure and vitamin D status (serum 25-hydroxyvitamin D [25(OH)D] levels) are associated with risk of first demyelinating events (FDEs) and to evaluate the contribution of these factors to the latitudinal gradient in FDE incidence in Australia. Methods: This was a multicenter incident case-control study. Cases (n = 216) were aged 18-59 years with a FDE and resident within one of 4 Australian centers (from latitudes 27°S to 43°S), from November...[Show more]
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