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Exploring the potential benefits of vaccinia virus complement controlprotein in controlling complement activation in pathogenesis of the central nervous system diseases

Kotwal, Girish J; Fernando, Nilisha; Zhou, Jianhua; Valter (Valter-Kocsi), Krisztina


Aging is a major risk factor for the development of diseases related to the central nervous system (CNS), such as Alzheimer's disease (AD) and age-related macular degeneration (AMD). In both cases, linkage studies and genome-wide association studies found strong links with complement regulatory genes and disease risk. In AD, both CLU and CR1 genes were implicated in the late-onset form of the disease. In AMD, polymorphisms in CFH, CFB and C2 were similarly implicated. The cost of caring for...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Molecular Immunology
DOI: 10.1016/j.molimm.2014.06.022


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