Sensitivity analysis of intention-to-treat estimates when withdrawals are related to unobserved compliance status
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Salim, Agus; Mackinnon, Andrew; Griffiths, Kathleen
Description
In the presence of dropout, intent(ion)-to-treat analysis is usually carried out using methods that assume a missing-at-random (MAR) dropout mechanism. We investigate the potential bias caused by assuming MAR when the dropout is related to unobserved compliance status. A framework to assess the magnitude of bias in the context of pre- and post-test design (PPD) with two treatment arms is presented. Scenarios with all-or-none and partial compliance level are investigated. Using two simulated...[Show more]
dc.contributor.author | Salim, Agus | |
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dc.contributor.author | Mackinnon, Andrew | |
dc.contributor.author | Griffiths, Kathleen | |
dc.date.accessioned | 2015-12-08T22:43:17Z | |
dc.date.available | 2015-12-08T22:43:17Z | |
dc.identifier.issn | 0277-6715 | |
dc.identifier.uri | http://hdl.handle.net/1885/37215 | |
dc.description.abstract | In the presence of dropout, intent(ion)-to-treat analysis is usually carried out using methods that assume a missing-at-random (MAR) dropout mechanism. We investigate the potential bias caused by assuming MAR when the dropout is related to unobserved compliance status. A framework to assess the magnitude of bias in the context of pre- and post-test design (PPD) with two treatment arms is presented. Scenarios with all-or-none and partial compliance level are investigated. Using two simulated data sets and actual data from an e-mental health trial, we demonstrate the utility of sensitivity analyses to assess the bias magnitude and show that they are plausible options when some knowledge of compliance behaviour in the dropout exists. We recommend that our approach be used in conjunction with methods of analysis which assume MAR in estimating the ITT effect. | |
dc.publisher | John Wiley & Sons Inc | |
dc.source | Statistics in Medicine | |
dc.subject | Keywords: article; clinical trial; cognitive therapy; controlled clinical trial; data analysis; depression; environmental factor; human; Internet; interpersonal communication; lifestyle; mathematical analysis; mathematical computing; medical research; mental health All-or-none compliance; Endpoint analysis; Markov chain Monte Carlo; Meta-analysis; Mixture models; Partial compliance; Prior information | |
dc.title | Sensitivity analysis of intention-to-treat estimates when withdrawals are related to unobserved compliance status | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 27 | |
dc.date.issued | 2008 | |
local.identifier.absfor | 111714 - Mental Health | |
local.identifier.ariespublication | U4146231xPUB146 | |
local.type.status | Published Version | |
local.contributor.affiliation | Salim, Agus, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Mackinnon, Andrew, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Griffiths, Kathleen, College of Medicine, Biology and Environment, ANU | |
local.bibliographicCitation.issue | 8 | |
local.bibliographicCitation.startpage | 1164 | |
local.bibliographicCitation.lastpage | 1179 | |
local.identifier.doi | 10.1002/sim.3025 | |
dc.date.updated | 2015-12-08T10:39:26Z | |
local.identifier.scopusID | 2-s2.0-40849119909 | |
local.identifier.thomsonID | 000255210700002 | |
Collections | ANU Research Publications |
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