Specific patterns of histone marks accompany X chromosome inactivation in a marsupial
Koina, Edda; Chaumeil, Julie; Greaves, Ian; Tremethick, David; Graves, Jennifer
The inactivation of one of the two X chromosomes in female placental mammals represents a remarkable example of epigenetic silencing. X inactivation occurs also in marsupial mammals, but is phenotypically different, being incomplete, tissue-specific and paternal. Paternal X inactivation occurs also in the extraembryonic cells of rodents, suggesting that imprinted X inactivation represents a simpler ancestral mechanism. This evolved into a complex and random process in placental mammals under...[Show more]
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