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Specific patterns of histone marks accompany X chromosome inactivation in a marsupial

Koina, Edda; Chaumeil, Julie; Greaves, Ian; Tremethick, David; Graves, Jennifer

Description

The inactivation of one of the two X chromosomes in female placental mammals represents a remarkable example of epigenetic silencing. X inactivation occurs also in marsupial mammals, but is phenotypically different, being incomplete, tissue-specific and paternal. Paternal X inactivation occurs also in the extraembryonic cells of rodents, suggesting that imprinted X inactivation represents a simpler ancestral mechanism. This evolved into a complex and random process in placental mammals under...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/37208
Source: Chromosome Research
DOI: 10.1007/s10577-009-9020-7

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