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Cytotoxic T cells specifically induce Fas on target cells thereby facilitating exocytosis-independent induction of apoptosis

Simon, Markus M; Waring, Paul; Lobigs, Mario; Nil, Ahmed; Tran, Thao (Thomas); Tha Hla, Ron; Chin, S; Mullbacher, Arno


Cytotoxic T (Tc) cells deficient in perforin lyse Fas-negative targets after lengthy incubation periods. This process is independent of granzymes, and killing occurs via the Fas pathway for the following reasons. Interaction of perforin-deficient Tc cells with Fas-negative targets leads to an up-regulation of Fas that is dependent on Ag recognition, de novo synthesis, and transport of proteins to the target cell surface. Treatment of effectors with brefeldin A, but not with the exocytasis...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Immunology


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