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Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

Silva, Diego; Daley, Stephen; Hogan, Jennifer; Lee, Sau Kuen (Candice); Teh, Charis; Hu, Daniel; Lam, Kong Peng; Goodnow, Christopher; Garcia De Vinuesa, Maria Carola


OBJECTIVE - To define cellular mechanisms by which B cells promote type 1 diabetes. RESEARCH DESIGN AND METHODS - The study measured islet-specific CD4 T cell regulation in T-cell receptor transgenic mice with elevated frequencies of CD4 T cells recognizing hen egg lysozyme (HEL) autoantigen expressed in islet β-cells and thymic epithelium under control of the insulin-gene promoter. The effects of a mutation in Roquin that dysregulates T follicular helper (Tfh) cells to promote activation and...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Diabetes
DOI: 10.2337/db10-1344


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