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The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation

Pardo, Julian; Aguilo, Juan Ignacio; Anel, A; Martin, Praxedis; Joeckel, Lars; Borner, C; Wallich, R; Mullbacher, Arno; Froelich, Christopher J; Simon, Markus M

Description

The granule exocytosis pathway of cytotoxic lymphocytes (Tc and NK cells) is critical for control of tumor development and viral infections. Granule-associated perforin and granzymes are key components in Tc cell-mediated function(s). On the basis of studies that showed granzymes A, B, C, K and M, to induce apoptosis in vitro, all granzymes were thought to also induce cell death in vivo. This review summarizes our present understanding of the biological processes elicited by purified granzyme A...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/37051
Source: Microbes and Infection
DOI: 10.1016/j.micinf.2009.02.004

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