Perturbation of chemical coupling by an endothelial Cx40 mutant attenuates endothelium dependent vasodilation by KCa channels and elevates blood pressure in mice.
Mutant forms of connexin40 (Cx40) exist in the human population and predispose carriers to atrial fibrillation. Since endothelial expression of Cx40 is important for electrical and chemical communication within the arterial wall, carriers of mutant Cx40 proteins may be predisposed to peripheral arterial dysfunction and dysregulation of blood pressure. We have therefore studied mice expressing either a chemically dysfunctional mutant, Cx40T202S, or wild-type Cx40, with native Cx40, specifically...[Show more]
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|Source:||Pflugers Archives European Journal of Physiology|
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