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Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism

Xu, Qian; Yuan, Yuan; Sun, Li-Ping; Gong, Yue-Hua; Xu, Ying; Yu, Xiu-Wen; Dong, Nan-Nan; Lin, David G; Smith, Paul; Li, Rachel


Identifying the genetic variants that alter MUC1 protein expression may further our understanding of the risk for development of gastric cancer (GC). We used PCR-SSPs to identify the genotype of MUC1 A/G polymorphism at its 568 site of exon 2 and immunohistochemistry to detect MUC1 protein expression in GC patients and non-cancer subjects and analyzed the association between this polymorphism and MUC1 protein expression. We found that the frequency of AA genotype was significantly high in the...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: International Journal of Oncology
DOI: 10.3892/ijo-00000449


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