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Structural and functional divergence of the newly identified GtrIc from its Gtr family of conserved Shigella flexneri serotype-converting glucosyltransferases

Ramiscal, Roy; Tang, Swee-Seong; Korres, Haralambos; Verma, Naresh


Glucosyltransferases (Gtrs) and O-acetyltransferase (Oac) are integral membrane proteins embedded within the cytoplasmic membrane of Shigella flexneri. Gtrs and Oac are responsible for unidirectional host serotype conversion by altering the epitopic properties of the bacterial surface lipopolysaccharide (LPS) O-antigen. In this study, we present the membrane topology of a recently recognized Gtr, GtrIc, which is known to mediate S. flenxeri serotype switching from 1a to 1c. The GtrIc topology...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Molecular Membrane Biology
DOI: 10.3109/09687680903552250


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