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T Follicular Helper Cells During Immunity and Tolerance

Linterman, Michelle; Garcia De Vinuesa, Maria Carola


Helper T cells are required for the generation of a potent immune response to foreign antigens. Amongst them, T follicular helper (Tfh) cells are specialized in promoting protective, long-lived antibody responses that arise from germinal centers. Within these structures, the specificity of B cell receptors may change, due to the process of random somatic hypermutation aimed at increasing the overall affinity of the antibody response. The danger of emerging self-reactive specificities is offset...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Book chapter
Book Title: Progress in Molecular Biology and Translational Science
DOI: 10.1016/S1877-1173(10)92009-7


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