T Follicular Helper Cells During Immunity and Tolerance
Helper T cells are required for the generation of a potent immune response to foreign antigens. Amongst them, T follicular helper (Tfh) cells are specialized in promoting protective, long-lived antibody responses that arise from germinal centers. Within these structures, the specificity of B cell receptors may change, due to the process of random somatic hypermutation aimed at increasing the overall affinity of the antibody response. The danger of emerging self-reactive specificities is offset...[Show more]
|Collections||ANU Research Publications|
|Book Title:||Progress in Molecular Biology and Translational Science|
|01_Linterman_T_Follicular_Helper_Cells_2010.pdf||1.05 MB||Adobe PDF||Request a copy|
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